Lynch syndrome, familial colorectal cancer colonoscopic surveillance Dutch: Lynch syndroom familiaire colorectaal carcinoom colonoscopische surveillance
Conditions
Interventions
Colonoscopic surveillance with both WLE and AFE in high risk patients (Lynch syndrome or familial colorectal cancer). In case of the detection of colorectal lesions (adenoma, colorectal cancer or hype
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older; 2. Patients with Lynch syndrome, defined according to the Amsterdam 2 criteria; 3. Patients with familial colorectal cancer (IKR Guidelines; www.oncoline.nl): A. One first degree family member with colorectal carcinoma diagnosed at a relative young age or in two second degree family members and; B. Lynch syndrome or Familial adenomatous polyposis is excluded.
Exclusion criteria
Exclusion criteria: 1. Under 18 years of age; 2. Patients with (attenuated) FAP; 3. Coagulopathy (prothrombin time 50 seconds) or anticoagulantia that can not be discontinued; 4. Patients with inflammatory bowel disease; 5. Patients with Peutz-Jeghers syndrome or juvenile polyposis; 6. Patients unable or not willing to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference between WLE and AFE for detection of adenomatous lesion or CRC during colonoscopy in patient with HNPCC or familial CRC. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Histological difference of the lesions detected only by WLE or only by AFE; 2. Duration of the procedure for WLE and AFE. | — |
Contacts
Public ContactD. Ramsoekh
Dept. of Gastroenterology and Hepatology Erasmus MC University Medical Center 's 's Gravendijkwal 230
Outcome results
None listed