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Clinical implementation of an uveitis prediction model

Clinical implementation of an uveitis prediction model

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON23206
Enrollment
250
Registered
2018-04-24
Start date
2018-06-01
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-infectious uveitis for at least 3 months.

Interventions

Sponsors

Oogziekenhuis Rotterdam (OZR)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: - Non-infectious uveitis for at least 3 months. - Age ≥ 18 years. - Informed consent.

Exclusion criteria

Exclusion criteria: - Major eye condition preventing any VA improvement or reduction (such as end stage glaucoma, end stage corneal diseases, end stage macular degeneration). - Suspected or proven infectious uveitis. - Masquerade syndromes (such as intraocular B cell lymphoma). - Patients for whom all data of the first year since onset of their uveitis are missing. - Patients for whom, since onset of their uveitis data from a substantial period of time (> 3 years) are missing.

Design outcomes

Secondary

MeasureTime frame
- Duration and dosage of immunosuppressive medication. - Change of inflammatory activity between entry and at 12 months. - Difference between predicted and achieved VA at 12 months. - Accuracy of predicted VA. - Difference between predicted and actual inflammatory activity at 12 months. - Accuracy of predicted activity. - Complications. - VFQ-25. - Change of outcomes for individual eyes as predicted by the model during the course of the 12 months follow up. - Change of prediction model perfomance (with respect to legal driving visual acuity, low vision, legal blindness) by means of internal validation. - IOP. - OCT. - The clinician's appraisal of the influence of the predictive model information on the prescribed therapy dosages.

Primary

MeasureTime frame
Change of visual acuity between entry and 12 months.

Contacts

Public ContactRene Wubbels

Rotterdam Ophthalmic Institute Postbus 70030

ROI@oogziekenhuis.nl+31 (0)10 4023449

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)