diabetes mellitus metabolic syndrome obesitas
Conditions
Interventions
- Phytosphingosine, twice a day 0.5 grams for 28 days
- Placebo, twice a day for 28 days
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male volunteers 2. Age > 18 years and 27 kg/m2 and 94 centimetres) 5. Fasting serum glucose > 5.6 mmol/L 6. Fasting serum insulin >15 mU/L 7. TG ≥ 1.7 mmol/L or HDL-C ≤ 1.03 mmol/L
Exclusion criteria
Exclusion criteria: 1. Any significant chronic disease 2. Renal, hepatic or another endocrine disease 3. Use of medication known to influence lipolysis and/or glucose metabolism 4. Difficulties to insert an intravenous catheter 5. Smoking 6. Recent blood donation (within the last 3 months) 7. Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Glucose metabolism:HOMA-IR, HOMA-β K-value by IVGTT • Plasma concentrations: Total cholesterol (TC), HDL-C-cholesterol (HDL-C), LDL-C-cholesterol (LDL-C), Triglycerides Glucose, insulin | — |
Secondary
| Measure | Time frame |
|---|---|
| • Anthropometric: Weight, height, waist and hip circumference, BIA • Plasma concentrations: ASAT, ALAT, gamma-GT, LDH, alkaline phosphatase fibrinogen, CRP | — |
Contacts
Public ContactM. Snel
LUMC, afdeling AIG (C4-70)
Outcome results
None listed