diabetes, insulin resistance
Conditions
Interventions
Mixed meal test: Liquid meal test (standard protocol) during which blood withdrawals are taken for 2-4 hours to measure glucose, insulin, bile acids and incretins.
Sponsors
AMC
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria, CTX patients: 1. Adult age (older than 18 years of age); 2. Body mass index 19‐30 kg/m2; 3. General good health (normal liver and renal function); 4. HbA1c below 7%; 5. Ability to give informed consent. Inclusion criteria, matched controls: Matched to CTX patients on individual basis. Preferably, these controls are unaffected healthy relatives to prevent differences in environmental factors (diet, faecal microbial composition, activity). If this is not possible, healthy matched control (age, length, height, gender) will be recruited.
Exclusion criteria
Exclusion criteria: Since CTX is a rare disorder, little exclusion criteria exist. However, patients that use medication that interferes with glucose metabolism such as oral antidiabetic medication or insulin are not included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose, bile acids and incretins during meal test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Energy expenditure. | — |
Contacts
Public ContactM.R. Soeters
Academic Medical Center (AMC) Department of Endocrinology & Metabolism, F5-162 P.O. Box 22660
Outcome results
None listed