glioblastoma multiforme (high-grade glioma)
Conditions
Interventions
Not applicable.
Sponsors
VU University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: For newly diagnosed patients: 1. Adult (> 18 years), 2. Radiologically suspected GBM prior to surgery, 3. histologically confirmed GBM after surgery, 4. treatment consisting of surgery followed by combined radiotherapy and chemotherapy, 5. written informed consent. For patients with GBM recurrence: 1. adult (> 18 years), 2. histologically confirmed GBM, 3. treatment consisting of surgery followed by chemotherapy, 4. written informed consent. For matched healthy controls: 1. adult (> 18 years), 2. written informed consent.
Exclusion criteria
Exclusion criteria: For patient groups: 1.use of centrally acting drugs, including corticosteroids, other than antiepileptic drugs, 2. psychiatric disease or symptoms, 3. insufficient mastery of the Dutch language, 4. inability to communicate adequately. For controls: 1. use of centrally acting drugs (including analgetics), 2. psychiatric disease or symptoms, 3. disorders of the central nervous system, 4. insufficient mastery of the Dutch language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are neurocognitive functioning and MEG-measures (synchronization likelihood and small-world features). | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Contacts
Public ContactM. Klein
Department of Medical Psychology - D343 VU University Medical Center
Outcome results
None listed