TMS response in healthy subjects.

Single pulse TMS: variability and reproducibility of MEP and EEG responses in healthy subjects.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23183

Enrollment

Registered

2010-06-16

Start date

2010-07-20

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy diagnosis TMS transcranial magnetic stimulation epilepsie diagnose TMS transcraniele magnetische stimulatie

Interventions

Our Transcranial Magnetic Stimulation equipment has a maximum output of 1,5 Tesla. Pulse duration is 400 microsec. 50 single TMS pulses will be given to 6 different brain areas (3 on each hemisphere)

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 60; 2. Righthanded.

Exclusion criteria

Exclusion criteria: 1. Personal history of epilepsy; 2. Lesion in the brain; 3. Hearing problems; 4. (Possible) pregnancy; 5. Metal objects in brain/skull; 6. Cochleair implant, implanted brain electrode or pacemaker; 7. Severe medical condition; 8. Take medications that lower the threshold for seizures spinal surgery, drains in spinal cord or ventricles; 9. Use illegal drugs.

Design outcomes

Primary

Measure	Time frame
The primary objective of this study is to evaluate if there exists a circadian variability of the MEP and EEG response to single pulse TMS in healthy subjects.	—

Secondary

Measure	Time frame
1. Investigate the accuracy of coil placement and the overall reproducibility of the MEP and EEG measurements performed with our equipment; 2. Explore additional signal analysis techniques for characterizing the EEG response; 3. Evaluate the TMS-EEG protocol for future studies in epilepsy patients; 4. Collect TMS-MEP and TMS-EEG data in healthy subjects to use as control data for future studies in epilepsy patients.	—

Measure

Time frame

1. Investigate the accuracy of coil placement and the overall reproducibility of the MEP and EEG measurements performed with our equipment; 2. Explore additional signal analysis techniques for characterizing the EEG response; 3. Evaluate the TMS-EEG protocol for future studies in epilepsy patients; 4. Collect TMS-MEP and TMS-EEG data in healthy subjects to use as control data for future studies in epilepsy patients.

—

Contacts

Public ContactEsther Braack, ter

Postbus 217

e.m.terbraack@tnw.utwente.nl+31 (0)53 4895310

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)