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Train hard is smart for the heart.

Train hard is smart for the heart: An exercise study on clinical outcome and mechanisms in heart failure patients.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON23141
Enrollment
84
Registered
2012-10-22
Start date
2011-07-12
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure Cardiac Failure Myocardial Failure Congestive Heart Failure Heart Decompensation

Interventions

1. 12 weeks of high-intensity interval exercise training, twice a week
2. 12 weeks of moderate-intensity continuous exercise training, twice a week
3. A control group who recieves usual care.

Sponsors

Radboud University Medical Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Heart failure NYHA classification II/III; 2. Ejection fraction < 45%; 3. Stable situation (clinically and pharmacological).

Exclusion criteria

Exclusion criteria: 1. Diabetes mellitus; 2. Hypercholesterolaemia; 3. Exercise-induced ischaemia; 4. Pre-menopausal females; 5. Pathology/disease that restricts patients from participation to exercise.

Design outcomes

Primary

MeasureTime frame
1. Physcial fitness; 2. Brachial artery NO-dependent endothelium-dependent vasodilation; 3. Forearm resistance artery vascular bed NO-(in)dependent vasodilation; 4. Contribution of ET to the baseline forearm resistance artery vascular tone.

Secondary

MeasureTime frame
1. Cardiac structure and function; 2. Blood parameters that are (in)directly related to the progression and prognosis of HF; 3. Contribution of ET or NO to the exercise-induced vasodilation of the forearm vascular bed.

Contacts

Public ContactNathalie M.M. Benda

Phililps van Leijdenlaan 15

N.benda@fysiol.umcn.nl+31 (024) 3614906

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)