gut complaints without medical diagnoses
Conditions
Interventions
The intervention group receives 5.5g GOS. The control group receives the same amount of maltodextrin powder. Both groups need to use these powder supplements, portion packed in sachets, daily for 21 d
Sponsors
FrieslandCampina
Eligibility
Inclusion criteria
Inclusion criteria: - Female - 25-45 years of age - Component (summed) score for gut complaints = 6 (based on bloating, flatulence, stomach ache, constipation, diarrhea)
Exclusion criteria
Exclusion criteria: - Any medical diagnosed disease underlying gut-related complaints, including Irritable Bowel Syndrome, celiac disease, Crohn’s disease, colitis, haemorrhoids, cancer, and/or any other disease considered relevant as determined during screening. - Use of antibiotics, opiates, anti-inflammatory drugs (NSAIDs) and/or metformin, and/or other medication that are known to affect the composition of the gut microbiota during the 14 days before inclusion. - Pregnant or lactating. - Self-reported lactose intolerance - Self-reported cow’s milk protein allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter is the gut comfort component score at day 21 of the study (component score is based on 5 questions: bloating, flatulence, stomach ache, constipation and diarrhea in the past 7 days) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Component (summed) score of gut comfort after 4 and 14 days. - Shifts in microbial composition (through 16s sequencing) after 21 days | — |
Contacts
Public ContactCarly Janssen
FrieslandCampina
Outcome results
None listed