1. Panic disorder
Conditions
Interventions
3. A waiting-list control condition of 14 weeks.
For both active treatments, paroxetine and CBT, follow-up period is 12 weeks.
1. Treatment with paroxetine 20 mg 1dd2 during 14 weeks
2. Cognitive behavioural therapy according to a treatment manual for panic disorder during 14 weekly sessions
Sponsors
1. Radboud University Nijmegen, Behavioural Science Institute, Nijmegen, the Netherlands: Prof. dr. C.A.L. Hoogduin, Dr. G.P.J. Keijsers;
2. GGz Nijmegen, Outpatient Department for Anxiety Disorders, Nijmegen
PO Box 7049, 6503 GM Nijmegen, the Netherlands.
Eligibility
Inclusion criteria
Inclusion criteria: 1. Panic disorder with/without agoraphobia (DSM-IV-criteria); 2. >60 years.
Exclusion criteria
Exclusion criteria: 1. The presence of severe psychiatric disorders (e.g. psychosis, major depression, bipolar disorder); 2. A severe somatic condition which would hinder appropriate application of CBT (e.g. severe cardiovascular disease); 3. A contraindication for prescribing paroxetine (e.g. co-occurring use of anti-coagulantia); 4. Current use of an antidepressant in an adequate dose; 5. Current and adequate psychological treatment; 6. Abuse or dependency of alcohol or psychoactive substances; 7. Dementia and a score of 23 or less on the Mini-Mental State Examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-report instruments for anxiety cogntions and phobic avoidance: scores on the Dutch adaptations of the Agoraphobic Cognitions Questionnaire (ACQ) and the Mobility Inventory avoidance scale (MI). | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-report instruments for depression and general psychopathology. Depressive symptoms were assessed with the Dutch adaptation of the Beck Depression Inventory (BDI) and general psychopathology was assessed with the Dutch adaptation of the Symptom Checklist (SCL-90). | — |
Contacts
Public ContactG.J. Hendriks
GGz Nijmegen, Outpatient Department for Anxiety Disorders, Nijmegen PO Box 7049,
Outcome results
None listed