Essential hypertension
Conditions
Interventions
- renal nerve stimulation
- renal denervation
- hyperemic pressure and flow measurements
Sponsors
VU medical center
Eligibility
Inclusion criteria
Inclusion criteria: - Essential hypertension - Three antihypertensive drugs, of which one a diuretic
Exclusion criteria
Exclusion criteria: - Age > 65 y - Ambulantory blood pressure > 180/110 mmHg in the absence of antihypertensive medication - Renal clearance < 60 ml/min (MDRD) - Secundairy hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - to study blood pressure changes in response to electrical stimulation pre- and post-ablation | — |
Secondary
| Measure | Time frame |
|---|---|
| - to study the effect of renal denervation on renal blood flow as expressed by renal flow reserve and resistance index. - to study the effect of renal denervation on office- and ambulatory blood pressure. - to study the effect of renal denervation on the efferent sympathetic nervous system activity as expressed by catecholamine levels and natriuresis. - to study the effect of RDN on central sympathetic nervous activity as expressed by heart rate variability and peripheral arterial tonometry. | — |
Contacts
Public ContactAlexander Nap
VUmc
Outcome results
None listed