Duchenne Muscular Dystrohy (DMD), dynamic training, functional training, In Dutch: Duchenne spierdystrofie, dynamische training, functionele training
Conditions
Interventions
The intervention of study 1 will consist of a low-to-moderate intensity dynamic exercise training. The control group will get the same training intervention after the waiting period. The intervention
Sponsors
Radboud University Nijmegen Medical Centre, department of Rehabilitation and department of Clinical Neurophysiology
Eligibility
Inclusion criteria
Inclusion criteria: Study 1 'Dynamic leg and arm exercise training for ambulant or recently wheelchair confined boys with DMD': 1. DNA established diagnosis of DMD; 2. Boys who are at the end of their ambulation, and; 3. Need more than 5 seconds to get up from the floor or are not able to raise from the floor, and/or; 4. Are not able to bicycle without assistance, and/or; 5. Are wheelchair dependent to move over long distance (more than 500m); 6. Boys who are recently wheelchair confined (approximately 1-2 years after they've stopped walking) and; 7. Are able to stand (un)supported; 8. Are able to touch the top of their head with both hands without assistance. Study 2 'Functional training with arm support for boys with DMD who have been wheelchair confined for several years': 1. DNA established diagnosis of DMD; 2. Boys who have been wheelchair confined for a few years (approximately 2-5 years after stop walking); 3. Boys who have problems with lifting their arms and reaching, and; 4. Are unable to touch the top of their head (at least one hand); 5. Are able to use their hands for daily activities; 6. Experience difficulties in lifting their arms and reaching.
Exclusion criteria
Exclusion criteria: Study 1: 1. Other disabling diseases influencing mobility; 2. Boys with a clinical symptomatic cardiomyopathy; 3. Boys 20 years old; 4. Boys who already use an arm support.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcomes for study 1 will be muscle endurance and functional abilities, as assessed with with bicycle ergometry and the Motor Function Measure (MFM). The primary outcome for study 2 will be functional abilities of the upper extremity (reaching and lifting), as assessed with the Action Research Arm test (ARA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes for both studies will be at the level of body functions and structures (e.g. muscle tissue), activities (e.g. activities in daily life) and participation (e.g. health related quality of life). | — |
Contacts
Public ContactMerel Jansen
UMC St Radboud Reinier Postlaan 4
Outcome results
None listed