Hip fracture, elective hip surgery, muscle loss, falls and fractures
Conditions
Interventions
Hospitalization of elderly women might be considered an important cause of loss of muscle mass and quality of life. However, the exact course of muscle mass loss during hospitalization remains to be d
2. During the operative treatment of the hip, the first muscle biopsy will be obtained from the vastus lateralis muscle of the treated leg
3. One blood sample (8 ml) will be collected during the primary surgical procedure and every 2 days during hospital admission, for a maximum of 10 days
4. For fracture patients randomly allocated to the group receiving nutritional intervention, supplementation of the nutritional supplement will start within 12 hours after surgery. Patients will recei
Sponsors
Maastricht University Medical Centre
TIFN: Top Institute for Food and Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: 1. Hip fracture or osteoarthritis of the hip; 2. >65 years of age; 3. Operative treatment.
Exclusion criteria
Exclusion criteria: 1. Co-morbidities and neuromuscular disorders of the lower limbs severely interacting with mobility; 2. Co-morbidities severely interacting with muscle metabolism of the lower limbs; 3. Known renal malfunction (Known renal malfunction without documented approval from nephrologist); 4. Known allergy to milk, milk products and soy; 5. Known galactosaemia; 6. A life-expectancy of less than 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameters in this study are the cross-sectional area of the quadriceps muscle and the cross-sectional area of type I and type II skeletal muscle fibers. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameters in this study are satellite cell content in the type I en type II skeletal muscle fibers, functional outcome 6 months after hospital admission (determined by the use of the PASE score and Hip Fracture Functional Recovery Scale), and quality of life (SF-36) 6 months after admission. Baseline subject characteristics will be obtained, including height, bodyweight, medical history, use of medication, mental status (determined by the MMSE), smoking, use of alcohol, use of drugs, level of habitual physical activity (determined by PASE, Hip Fracture Recovery Scale), and quality of life (SF-36). The nutritional status of the patients will also be measured, using the MNA and MUST questionnaires. Lean body mass and bone mineral density will be determined by DEXA. In addition, blood samples will be analyzed for HbA1c, CRP, calcidiol, and TNF-á. | — |
Contacts
Public ContactI.F. Kramer
Outcome results
None listed