Bloating, dyspepsia Opgeblazen gevoel, dyspepsia, maagklachten
Conditions
Interventions
Consumption of 500 mL beer or carbonated soft drink.
Sponsors
Wageningen UR (University & Research centre)
Eligibility
Inclusion criteria
Inclusion criteria: -Age: 18-40 years -BMI: 18.5 – 25.0 kg/m2 -Healthy (as judged by the participant) -On average consuming more than 1 unit of beer per month but less than 13 units per week. -On average consuming more than 1 unit of soft drink per month but less than 13 units per week. -Willing to be informed about incidental findings of pathology and approving of reporting this to their general physician.
Exclusion criteria
Exclusion criteria: -Drug use or medical conditions which may interfere with normal functioning of the digestive tract. -Drug use or medical conditions which may interfere with normal functioning of the circulatory system -Drug use or medical conditions which may lead to unreliable fMRI results (including, but not limited to neurological conditions) -Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening -For women: having the intention to become pregnant, pregnancy during the last 6 months or lactating - Smoking on average more than one cigarette/cigar a day -Having a contra-indication to MRI scanning including, but not limited to, metal in the body and claustrofobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Gastric measures (MRI): Gastric volume, air and liquid gastric compartments. 2) Subjective ratings of fullness and bloating. 3) Changes in regional brain activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective feelings of appetite, thirst and nausea; obtained on scan days just before and after participants are scanned. | — |
Contacts
Public ContactJac Niessen
Wageningen UR (University & Research centre) - Bestuurscentrum, Gebouw 104, Droevendaalsesteeg 4
Outcome results
None listed