adrenal incidentaloma adrenocortical carcinoma urinary steroid profiling
Conditions
Interventions
Not applicable.
This is not an interventional study per se, as patients with an adrenal incidentaloma are evaluated according to current management guidelines.
The diagnostic value of urinary stero
Sponsors
University Medical Center Groningen
Amsterdam Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: - adrenal mass > 1 cm in diameter incidentally discovered during CT-scanning, performed for reasons other than an evaluation for adrenal disease - age 18 years or older
Exclusion criteria
Exclusion criteria: - extra-adrenal malignancy (i.e. active or past medical history of malignancy, except for basal cell carcinoma) - radiologic diagnosis of simple cyst or bilateral adrenal masses - allergy to radiocontrast - renal insufficiency (i.e. eGFR <30 /min/1.73m2) - pregnancy - inability to understand written Dutch
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter is the difference in cost-effectiveness of the current management strategy based on repeat CT-scanning to detect adrenocortical carcinoma among patients with an adrenal incidentaloma compared with a strategy using a single baseline urinary steroid profiling. | — |
Secondary
| Measure | Time frame |
|---|---|
| • frequency of adrenocortical carcinoma among patients with an adrenal incidentaloma at baseline or during follow-up. • determination of the percentage of adrenal incidentaloma that fulfils the criteria of a malignant CT-phenotype at baseline or during follow-up. • determination of the pathologic diagnosis in patients who underwent adrenalectomy. • QoL in patients with an adrenal incidentaloma at baseline and during follow-up. • frequency distribution between hormonal hypersecreting and non-functional adrenal incidentaloma. • conversion rate of a non-functioning adrenal incidentaloma towards a hypersecreting adrenal incidentaloma during follow-up. • costs of diagnostic procedures and surgical interventions. | — |
Contacts
Public ContactM.N. Kerstens
Department of Endocrinology University Medical Center Groningen
Outcome results
None listed