obesity, type 2 diabetes
Conditions
Interventions
Subjects will reduce their daily caloric intake with 50% for 4 weeks. Subjects will be randomized into either a hypocaloric diet group where 15% of total kcal have to be consumed with breakfast, 35% k
Sponsors
AMC
Eligibility
Inclusion criteria
Inclusion criteria: men >50 y BMI >30 fasting glucose > 5.6 and/or insulin > 74 Stable weight three months prior to study inclusion
Exclusion criteria
Exclusion criteria: Use of any medication except for those related to treatment of components of the metabolic syndrome (excluding insulin, oral glucose lowering drugs, beta-blockers) Any actual medical condition except for treated hypothyroidism and the metabolic syndrome History of any psychiatric disorder Shift work Irregular sleep pattern Intensive sports (>3/week) Restrained eaters History of eating disorders (anorexia, binge eating, bulimia) Smoking, XTC, amphetamine or cocaine abuse Alcohol abuse (>3/day) Contraindication MRI Lactose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Insulin sensitivity (hyperinsulinemic euglycemic clamp) 2. Diencephalic SERT ( [123I]FP-CIT SPECT) 3. Brain 5-HT neurotransmission (pharmacological MRI (phMRI) using citalopram). | — |
Secondary
| Measure | Time frame |
|---|---|
| Motivation and impulse control Abdominal and liver fat Circulating hormones and substrates: blood drawing Sleep duration Resting energy expenditure Sympathetic and parasympathetic activity Feeding behaviour | — |
Contacts
Public ContactRuth Versteeg
Outcome results
None listed