Dutch Belgian randomised lung cancer screening trial (NELSON).

NEderlands Leuvens Longkanker Screenings Onderzoek (NELSON-screening trial) in high risk subjects.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22971

Enrollment

15600

Registered

2006-03-22

Start date

2003-08-16

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

1. Screen arm: a. 16-detector multi-slice computed tomography of the chest in year 1, 2 and 4 of the study

b. Pulmonory function test

c. Blood sampling

d. Questionnaires

e. Smoking cessation advice for current smokers. 2. Control arm: smoking cessation advice for current smokers

3. A sample of controls: a. Pulmonory function test

b. Blood sampling

c. Questionnaires.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Born between 1928 and 1956; 2a. Smoked > 15 cigarettes/day during > 25 years or; 2b. Smoked > 10 cigarettes/day during > 30 years; 3. Current or former smokers who quit smoking =< 10 years ago.

Exclusion criteria

Exclusion criteria: Subjects 1. With a moderate or bad self-reported health who were unable to climb two flights of stairs; 2. With a body weight >= 140 kilogram; 3. With current or past renal cancer, melanoma or breast cancer; 4. With lung cancer diagnosed less than 5 years ago or 5 years or more ago but still under treatment; 5. Who had a chest CT examination less than one year before they filled in the first NELSON questionnaire.

Design outcomes

Primary

Measure	Time frame
Lung cancer mortality (reduction).	—

Secondary

Measure	Time frame
1. Cost-effectiveness; 2. Quality of Life.	—

Contacts

Public ContactHarry J. Koning, de

Room AE-238, Erasmus MC P.O. Box 2040

h.dekoning@erasmusmc.nl+31 (0)10 7038460

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)