Glutamine-enriched enteral feeding in very low birth weight infants.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22969

Enrollment

107

Registered

2005-09-12

Start date

2001-09-16

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gut adaptation and modulation of the immune response in very low birth weight infants.

Interventions

Enteral glutamine supplementation in a dose of 0.3 g/kg/day between days 3 and 30 of life versus isonitrogenous placebo supplementation (alanine).

Eligibility

Inclusion criteria

Inclusion criteria: Infants with a gestational age < 32 weeks and/or a birth weight < 1500 grams.

Exclusion criteria

Exclusion criteria: Major chromosomal or congenital anomalies.

Design outcomes

Primary

Measure	Time frame
Primary outcome of the study is time to full enteral feeding, defined as a feeding volume ¡Ý120 mL/kg/day.	—

Secondary

Measure	Time frame
Furthermore, other parameters of feeding tolerance, infectious morbidity, and short-term outcome are evaluated. In addition to clinical outcome, intestinal permeability, faecal flora, plasma Th1/Th2 cytokine concentrations and plasma amino acid profiles are determined during the 30 day study period.	—

Contacts

Public ContactA. Berg, van den

VU University Medical Center, Department of Pediatrics, Division of Neonatology, De Boelelaan 1117

a.vandenberg@vumc.nl+31 (0)20 4442413

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)