Post partum hemorrhage, restritive fluid resuscitation, coagulopathy
Conditions
Interventions
Restrictive fluid resuscitation: standaard care means suppletion of 1,5-2 times the amount of lost blood, in the study group 0,75-1x the amount of blood loss will be administered.
Sponsors
Maastricht Universitair Medisch Centrum
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pregnant women attending the outpatient clinic; 2. Pregnant and delivery/labor, > 24 weeks; 3. Age ≥ 18 years; 4. Informed consent; 5. Mentally competent, understanding Dutch language.
Exclusion criteria
Exclusion criteria: 1. Labor < 24+0 weeks; 2. Prophylactic or therapeutic anticoagulant therapy (carbasalate calcium within the last 10 days or low molecular weight heparins within last 48 hours); 3. Known congenital, coagulation disorders; 4. Pre-eclampsia (higher risk of low plasma volume, higher risk of volume overload).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In women with early, mild PPH (blood loss 500-750ml) we would like to establish whether controlled hypotensive resuscitation strategy reduces the progression to severe PPH compared to care as usual. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To evaluate if controlled hypotensive resuscitation reduces transfusion requirements; 2. To evaluate if controlled hypotensive resuscitation leads to less coagulopathies. | — |
Contacts
Public ContactNatascha Lange, de
Postbus 5800
Outcome results
None listed