A new approach to determine the time of incidence of traumatic brain injury

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON22939

Enrollment

Registered

2020-12-22

Start date

2020-12-22

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subacute subdural hematoma and chronic subdural hematoma

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: • 18 years or older; • the patients, or their legal representative, have signed an informed consent; • have a traumatic subacute or chronic SDH; • the date of trauma must be known

Exclusion criteria

Exclusion criteria: • recurrent SDH; • previous surgery for SDH in the past 365 days; • inability to obtain informed consent from the patient (or when the patient has a depressed level of consciousness their legal representative), including language barrier.

Design outcomes

Primary

Measure	Time frame
The main study parameters are the concentrations over time of six biomarkers (UCHL1, ICAM5, NFH, MBP, GFAP and NGF) in subdural blood. GFAP Glial fibrillary acidic protein ICAM-5 Intercellular adhesion molecule 5 MBP Myelin basic protein NFH Neurofilament heavy chain NGF Nerve growth factor UHCL1 Ubiquitin C-terminal hydrolase L1	—

Secondary

Measure	Time frame
The second study parameters are hemoglobin derivatives (HbO2, met-Hb, HC, Biliverdin and Bilirubin) in subdural blood. Hb Hemoglobin HbO2 Oxyhemoglobin HC Hemichrome	—

Contacts

Public ContactRoger Lodewijkx

Amsterdam UMC location AMC

r.lodewijkx@amsterdamumc.nl0205669111

Outcome results