Reduced fetal movements
Conditions
Interventions
Expedited delivery is pursued in women with an abnormal CPR (<1.1) in the open study arm. In this case we aim to start delivery within 16 hours or an elective caesarean section will be advanced. Women
Sponsors
University Medical Center of Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Singleton pregnancies in cephalic presentation and normal cardiotocograph presenting with RFM beyond 37 weeks gestation
Exclusion criteria
Exclusion criteria: • Small for gestational age, defined as an abdominal circumference <p10 and/or estimated fetal weight <p10; • Planned caesarean delivery, except an elective repeat caesarean delivery; • Abnormal (ultrasound) findings that indicate immediate need for delivery; • Planned delivery within four days of presentation with RFM; • Major congenital malformations or chromosomal abnormalities that can influence pregnancy outcomes chosen for this study; • Unregulated diabetes mellitus; • Maternal age <18 years; • Inability to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite perinatal outcome: stillbirth and neonatal mortality ( 7 days) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Mild and other neonatal outcomes (hypoglycaemia, hypothermia, admittance to neonatal ward). • Long-term child outcomes (general health, development and behaviour). • Maternal outcomes (health related quality of life, anxiety pre- and postpartum, hypertensive disorders of pregnancy). • Maternal serum markers (PlGF, sFLt-1, and PlGF/sFLt-1 ratio). • Accuracy of standard placental immunohistochemistry. | — |
Contacts
Public ContactDr. Sanne J. Gordijn (PI)
UMC Groningen
Outcome results
None listed