Kidney transplantation
Conditions
Interventions
Low dietary sodium intake (~50 mmol/day = 3 grams salt/day) vs liberal dietary sodium intake (~150 mmol/dayg = 9 grams salt/day). This is a crossover design with an intervention period of 6 weeks each
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written informed consent; 2. Male and female transplant recipients; 3. Transplantation performed in the University Medical Center Groningen or Academic Medical Center Amsterdam; 4. Patients that are one year after transplantation or beyond; 5. 18 years or older; 6. Stable renal function at study entry; 7. Use of RAAS-blockade: either an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB).
Exclusion criteria
Exclusion criteria: 1. Blood pressure 160/95 mmHg; 3. Complaints or signs of orthostatic hypotension; 4. Creatinine clearance 1.5 g/24h; 6. Being on a cyclosporine withdrawal regimen; 7. Rejection of the allograft for which a switch in immunosuppressive medication is necessary; 8. Severe general diseases or mental disorders making the participation in the study impossible; 9. Pregnancy; 10. Drug abuse; 11. No sufficient knowledge of the Dutch language to participate in the study; 12. Participation in another intervention study during or within a month prior to this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Blood pressure; 2. Number of antihypertensives used. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Extracellular volume, as measured by volume marker NT-proBNP; 2. Renal damage, as measured by urinary protein/albumin excretion, and urinary excretion of tubulointerstitial damage markers. | — |
Contacts
Public ContactL.V. Vries, de
Hanzeplein 1
Outcome results
None listed