1. Percutaneous coronary intervention
Conditions
Interventions
Intracoronary adenosine injection versus placebo.
Sponsors
University Medical Center Groningen,
Thoraxcenter, Dept Cardiology.
Eligibility
Inclusion criteria
Inclusion criteria: 1. A diagnosis of acute MI defined by chest pain suggestive for myocardial ischemia for at least 30 minutes, with a time from onset of symptoms of less than 12 hours, before hospital admission. 2. An ECG with ST- segment deviation of more than 0.1 mV in 2 or more leads. 3. Thrombus aspiration performed. 4. Verbal followed by written informed consent. 5. 18 years or older.
Exclusion criteria
Exclusion criteria: 1. Need for emergency coronary artery bypass grafting (CABG). 2. Presence of cardiogenic shock. 3. Known existence of a life-threatening disease with a life expectancy of less than 6 months. 4. Receiving pharmacotherapy for chronic obstructive pulmonary disease (COPD). 5. Inability to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Residual ST-segment deviation at 30 to 60 minutes after the procedure. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Myocardial blush grade; 2. ST-segment deviation resolution; 3. Enzymatic infarct size; 4. Distal embolization on coronary angiography; 5. Post-procedural TIMI flow; 6. Clinical outcome at 30 days and 12 months. | — |
Contacts
Public ContactPieter-Jan Vlaar
University Medical Center PO Box 30 0001
Outcome results
None listed