Effects of acute elevation of circulating fatty acids on cardiac lipid accumulation in healthy lean young men.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22845

Enrollment

Registered

2009-07-20

Start date

2008-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

possible mechanism for cardiac lipid accumulation in obesity is studied in healthy lean mean.

Interventions

Subjects cycled for 2 hours at 50% of the predetermined maximal work load in the fasted state and stay fasted during a three hour recovery period. This procedure is known to increase free fatty acid c

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male sex; 2. Age: 18-35 years; 3. BMI: 18-25; 4. Stable dietary habits (no weight gain or loss of >8% of bodyweight in the last 6 months); 5. No medication.

Exclusion criteria

Exclusion criteria: 1. Known cardiovascular disease, diabetes or dyslipididemia; 2. Contra-indication for MRI (electronic implants, iron containing corpora alinea in eyes, certain hearing aids and certain artificial heart valves); 3. Weight gain/loss > 8% of body weight; 4. Medication use.

Design outcomes

Primary

Measure	Time frame
Cardiac lipid content after high or low free fatty acid condition.	—

Secondary

Measure	Time frame
Cardiac function (by MRI) and cardiac energy status (determined by 31P-MRS).	—

Contacts

Public ContactPatrick Schrauwen

Postbus 616 Department of Human Biology Maastricht University Medical Center

p.schrauwen@hb.unimaas.nl+31(0)43-388 15 02

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)