The value of diffusion-weighted MR imaging and biomarkers in cerebrospinal fluid in acute spinal cord injury as predictors of outcome.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22830

Enrollment

Registered

2008-07-15

Start date

2008-08-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal cord injury, biomarkers, MRI-DWI

Interventions

Within 24 hour after the initial trauma all patients with SCI recieve a MRI and a DWI examination. Within 72 hours after the initial trauma all patients with SCI will be operated on the cervical and/

Eligibility

Inclusion criteria

Inclusion criteria: 1. Closed spinal cord injury 2. Associated neurologic deficit 3. Primarily referred to UMC St. Radboud 4. Glasgow Coma Scale of 15

Exclusion criteria

Exclusion criteria: 1. Penetrating spinal cord injury 2. Normal neurologic examination 3. Ischaemic spinal cord injury 4. Traumatic brain injury 5. Pre-existent neurological disorder

Design outcomes

Primary

Measure	Time frame
1. Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using MRI 2. Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using DWI 3. The values of Apparent Diffusion Coefficients (ADC) in the lesion and in normal spinal cord in 10-3 mm2/s measured using DWI 4. The concentrations of Neuron Specific Enolase, Glial Fibrillary Acidic Protein, S-100ß, Neurofilament Protein, Tau and Myelin Basic Protein in CSF in patients with SCI. 5. Evaluation of the ASIA classification system and SCIM of all patients at different times	—

Measure

Time frame

1. Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using MRI 2. Size of the lesion (hemorrhage, edema, contusion) in the spinal cord measured in millimetres using DWI 3. The values of Apparent Diffusion Coefficients (ADC) in the lesion and in normal spinal cord in 10-3 mm2/s measured using DWI 4. The concentrations of Neuron Specific Enolase, Glial Fibrillary Acidic Protein, S-100ß, Neurofilament Protein, Tau and Myelin Basic Protein in CSF in patients with SCI. 5. Evaluation of the ASIA classification system and SCIM of all patients at different times

—

Contacts

Public ContactM.H. Pouw

Radboud University Nijmegen Medical Centre Department of Orthopaedic surgery PO Box 9101

M.Pouw@orthop.umcn.nl+31 (0)24 3613918

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)