Type 2 diabetes
Conditions
Interventions
Subjects are randomly assigned, by envelope, to an acute exercise bout with acipimox administration, followed one week later by an acute exercise bout with placebo intake, followed one week later by a
Sponsors
Universiteit Maastricht Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: Twelve male T2DM patients (fasting blood glucose level >125mg/dl, and/or HbA1c >6.5%) will be included. Subjects with following characteristics will be included: age 45-70 years, body mass index 27.5-35.0 kg/m², sedentary (<2 hours sport/week), treated by oral blood glucose lowering medication, no exogenous insulin therapy, no history of coronary events/revascularization, absence of chronic pulmonary, renal disease, gastric complaints/disease, and/or orthopedic disease that interferes with exercise, no involvement in exercise training and/or caloric restriction program for at least one year.
Exclusion criteria
Exclusion criteria: Exogenous insulin therapy, history of coronary events/revascularization, presence of chronic pulmonary, renal disease, gastric complaints/disease, and/or orthopedic disease that interferes with exercise, involvement in exercise training and/or caloric restriction program for at least one year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour glycemic control: serial measurements of blood glucose, insulin levels, and calculation of HOMA-IR index. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood free fatty acid, triglyceride, and lactate levels. | — |
Contacts
Public ContactD. Hansen
Maastricht University
Outcome results
None listed