Chronic perniones Chilblains
Conditions
Interventions
Local application on the affected skin parts of betamethasonvalerate 0,1% cream twice a day for a period of six weeks.
Sponsors
Radboud University Nijmegen
department Womens Studies Medicine
(head: Prof. Dr. A.L.M. Lagro Janssen).
Eligibility
Inclusion criteria
Inclusion criteria: Population: Patients with complaints of chronic chillblains referred to us in the winters of 2009-2010, 2010-2011 and 2011-2012 by GPs in the north west of the Netherlands. And subjects who attended our 2003-2004 study on the effect of vitamin D3. Inclusion criteria: 1. Age: As of 18 years old; 2. Able to follow instructions and complete a diary; 3. At least 3 weeks of complaints at inclusion: Itching or painful lesions at fingers, toes or other places at the feet or te thighs (the Kibes). The complaints started in the period december to february. There may be swelling and there may be ulceration but these criteria are not obligate.
Exclusion criteria
Exclusion criteria: 1. A patient history of inflammatory disease; 2. Pregnancy; 3. Breast feeding; 4. Actual use of a calcium entry blocker; 5. Use of corticosteroid containing cream or ointment in the past four weeks; 6. Ulcera on the places to be treated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We consider the intervention to be effective when a reduction of complaints or disability occurs of 10mm, as recorded by the subjects on a 100mm Visual analogue scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary we register side effects: skin irritation an signs of skin atrophy. | — |
Contacts
Public ContactI.H. Souwer
Middelie 91
Outcome results
None listed