None listed
Conditions
Interventions
Spinal anesthesia at the level of L3-L4 with 3 mL bupivacaine 0.5% after local anesthesia with lidocaine 1%. Placebo will exist of local anesthesia with lidocaine after which a punction will take plac
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Healthy male, right handed volunteers between 18 and 45 years old.
Exclusion criteria
Exclusion criteria: 1. Obesity (BMI > 30); 2. Significant history of any cardiac or vascular disorder, asthma or other pulmonary disease, major gastrointestinal abnormalities, peptic ulceration, hepatic, neurological, psychiatric, haematological (including bleeding disorders), endocrine, renal, or major genitourinary disease; 3. History of illness, condition or medication use that, in the opinion of the investigator, might interfere with optimal participation, confound the results of the study or pose additional risk in administering spinal anesthesia to the subject; 4. History of chronic alcohol or illicit drug use; 5. Metal medical devices like pacemakers, knee or hip prosthesis, ear implants, vessel clips, subcutaneous insulin pumps or carries metal particles (e.g. metal splinter in the eye) inside the body; 6. Claustrophobia; 7. Allergy to study medications; 8. Not able to maintain a regular diurnal rhythm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting-state fMRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Heat pain tests (heat probe on lower arm); 2. Sedation scoring (self test and observer test); 3. Block height. | — |
Contacts
Public ContactAlbert Dahan
Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600
Outcome results
None listed