Prehypertension, defined as an avarage office blood pressure of 130-139/85-89 mmHg.
Conditions
Interventions
Individuals are randomized to receive either lisinopril 10mg daily for three weeks followed by a forced titration to lisinopril 20mg daily or matched placebo for a period of one year. This is followed
Sponsors
Academic Medical Centre
Dept.Vascular Medicine
Meibergdreef 9
1105 AZ Amsterdam
The Netherlands
Tel +31 20 5669111
Eligibility
Inclusion criteria
Inclusion criteria: Otherwise healthy persons aged 18-40 years with 3 cardiovascular risk factors or less and an average blood pressure of 130-139 systolic/below 90 mmHg diastolic and/or below 130 systolic/ 85-89 mmHg diastolic on 2 separate visits with an interval of 1 week and measured by a validated automatic blood pressure device.
Exclusion criteria
Exclusion criteria: 1. Previous antihypertensive treatment; 2. Any chronic use of prescribed oral medication except oral contraceptives; 3. An elevated baseline serum glucose (>7.0 mmol/L) or elevated serum creatinine(> 95 ummol/L for women and >110 ummol/L for men); 4. Women with a wish to become pregnant in the treatment period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in ambulatory blood pressure between lisinopril and placebo 2 years after cessation of active treatment compared to baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in left ventricular mass (index) and microalbuminuria between lisinopril and placebo 2 years after cessation of active treatment compared to baseline. | — |
Contacts
Public ContactB. Bogaard, van den
Academic Medical Center Department of Vascular Medicine (room F4-255) P.O. Box 22660
Outcome results
None listed