Postprandial metabolism of protein in healthy volunteers Verteringskinetiek van eiwit bij gezonde mensen
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: • Healthy as assessed by a health and lifestyle questionnaire and normal blood clinical laboratory tests for haemoglobin, kidney and liver functioning • Age between 18 and 50 y (boundaries included) at day 01 of the study • Body mass index (BMI) between 19 and 25 kg/m2 (boundaries included) • Appropriate veins for blood sampling (judged by a study nurse or medical doctor) • Willing to abstain from blood donation one month before and during the study • Willing to abstain from the use of protein supplements during the study period • Signed informed consent • Willing to comply with the study procedures
Exclusion criteria
Exclusion criteria: • Any metabolic, gastrointestinal, inflammatory or chronic disease (such as diabetes, anaemia, hepatitis, cardiovascular disease) • History of gastro-intestinal surgery • History of liver dysfunction (cirrhosis, hepatitis) or liver surgery • Kidney dysfunction (eGFR 16 hours per week) • Current smoker • Alcohol intake (≥3 glasses of alcoholic beverages per day) • Pregnant, lactating or wishing to become pregnant in the period of the study (self-reported) • Use of hard drugs • Known allergies towards the products used in the study • Not willing to consume chicken broth • Participation in another clinical trial at the same time • Being an employee of the responsible and executing research facility
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum amino acids | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum glucose, insulin (t=0 until t=180; each 15-30 minutes) Gastro-intestinal complaints (during 4 days) | — |
Contacts
Wageningen Food & Biobased Research