Cocoa and chocolate products have generated significant interest due to their association with various health-protective and therapeutic activities. Cocoa and chocolate are rich sources of flavan-3-ols, which are present in monomeric and polymeric forms.
Conditions
Interventions
Five single doses of a cocoa products in randomised order with a minimal 5-day interval. Four of those cocoa products contain a high level of flavenols and are commercially available. One product is n
Sponsors
ProDigest BVBA
Technologiepark 3, 9052 Zwijnaarde, België
Tel: +32/ 9 264 59 78
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults between 20 and 45 years old; 2. Non-smoking individuals; 3. Capable and willing to sign the Informed Consent Form at voluntary basis; 4. Considered healthy based on their medical history and physical examination; 5. Female volunteers do not intend to become pregnant prior to or during the study and using adequate contraception.
Exclusion criteria
Exclusion criteria: 1. Clinically significant abnormal liver biochemistry; 2. Clinically significant abnormal serum creatinin; 3. Abnormal body mass index; 4. Use of concomitant medications or supplements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the blood concentration - time curve (AUC). | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximal blood concentration (Cmax) and time to maximal blood concentration (Tmax). | — |
Contacts
Public ContactF. Vanmolkot
P. Debyelaan 25
Outcome results
None listed