suicide, zelfdoding, emotion regulation (emotie regulatie)
Conditions
Interventions
treatment as usual (according to current guidelines)
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: All participants (N=94) - At least 18 years of age and not older than 60, in order to only include adults and avoid aging related pathology in information processing (Salthouse, 2010) and brain volumes (Li, et al., 2012), while still including the largest risk group (males between 40-60 years [CBS, meer zelfdodingen, 30-06-2016]) - Written informed consent Suicide attempt patients (N=46) - Had a recent suicide attempt as judged by a psychiatrist (not more than two weeks ago at moment of scanning) according to the above mentioned definition Patient controls (N=24) - Matched to suicide attempt patients on age, sex, education, and handedness - Matched to suicide attempt patients on psychopathology - No current suicidal ideation defined by a BSS=0 - Never attempted suicide Healthy controls (N=24) - Matched to suicide attempt patients on age, sex, education, and handedness - No current suicidal ideation defined by a BSS=0 - Never attempted suicide
Exclusion criteria
Exclusion criteria: All participants: - Presence of a neurological disorder - A suicide attempt in light of auto-euthanasia in presence of a terminal somatic illness or as cause of a psychotic delusion - Visual or hearing problems that cannot be corrected - Insufficient knowledge of the Dutch language - Not able to undergo 3 Tesla MRI scanning, these criteria include: (suspected) pregnancy, claustrophobia, MR incompatible implants or objects in the body (such as ear prostheses or other metal implants, operating clips or metal particles in the eye), tattoos containing pigments that form a safety risk, the refusal to be informed (by notifying the participants physician) of structural abnormalities that could be detected during the experiment. - Medication that could influence the brain metabolism For Healthy controls - A past or current psychiatric disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is brain activation/connectivity measured with functional magnetic resonance imaging (fMRI) during emotion regulation. For the second objective, the main study outcome will be suicidal ideation (measured with the Beck suicidal ideation scale) at 1, 3, 6, and 12 months after attempt. The third objective is the difference in brain activation/connectivity between the baseline fMRI measurement and the follow up scan after 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| As second outcome measure we will investigate the brain activation/connectivity during tasks of affective forecasting and reading the mind in the eyes and during resting state. The Levels of emotional awareness scale (LEAS) and Bermond-Verbal Alexithymia questionnaire (BVAQ) will be used as moderating factors to investigate the association between suicidal attempt/ideation and brain activation. A secondary outcome measure for the second objective will be a new fatal or nonfatal suicide attempt during the follow-up period. Therefore, we will ask participants whether they had a (nonfatal) suicide attempt since the baseline measurement. To describe the patients and characterize possible subgroups of patients (those who will and those who will not benefit from treatment, objective 2), we will include the Emotion Regulation Questionnaire (ERQ), Temporal Experience of Pleasure Scale (TEPS), Orbach & Mikulincer Mental Pain Scale (OMMP), Beck Hopelessness Scale (BHS) and Barratt Impulsivity Scale (BIS), because use of emotional regulation strategies, experience of pleasure, mental pain, feeling hopelessness and being impulsive are all important factors that could lead to suicidal behavior. Moreover, these variables could be used as regressor in the analyses to investigate their influence no brain activation/connectivity. | — |
Contacts
Public ContactEsther Opmeer
University Medical Center Groningen
Outcome results
None listed