Nitrate and sucrose: GI function

The effect of dietary nitrate and sucrose on GI function during exercise

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22715

Enrollment

Registered

2017-03-20

Start date

2017-01-10

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

On each test day the subjects will perform 60 min of cycling at 70% Wmax, were the effect of each intervention on GI parameters will be investigated: NIT: 1.1 g of NaNO3 (sodium nitrate) dissolved in

Eligibility

Inclusion criteria

Inclusion criteria: - Healthy (see exclusion criteria below) - 18 - 40 years of age - 18.5 4.5 W/kg

Exclusion criteria

Exclusion criteria: - Diagnosed or on medication for: Cardiovascular disease; Chronic Obstructive Pulmonary Disease (COPD); Rheumatoid arthritis (RA); Inflammatory bowel disease (IBD); Morbus Crohn and colitis ulcerosa; Irritable bowel syndrome; Inflammatory systemical diseases; Diabetes Mellitus; Diabetes Insipidus; Hypo- or hyperthyreoidism; Kidney failure; Donation of blood within the last 3 months; Cancer, Alcohol use of > 5 units per day; Drugs abuse; Use of regular medication; Oversensitive for sucrose; Phenol Keton Uria (PKU); Acute porphyria in the past. - Smoking - Currently supplementing diet with nitrate

Design outcomes

Primary

Measure	Time frame
Intestinal damage: plasma intestinal fatty acid binding protein (I-FABP)	—

Secondary

Measure	Time frame
• Splanchnic perfusion, measured by gastrotonometry and arterial blood sampling • Plasma nitrate and nitrite concentrations • Plasma glucose • Resting blood pressure	—

Contacts

Public ContactKristin Jonvik

kristin.jonvik@maastrichtuniversity.nl+31 653879054

Outcome results