Heavy menstrual bleeding / Hevig menstrueel bloedverlies Menorrhagia / menorrhagie Menstrual cycle / menstruele cyclus Fibrinolysis / fibrinolyse Clot lysis time / Clot lysis tijd
Conditions
Interventions
Patients ar asked to fill out a questionnaire and to withdraw blood 4 times (one time every week, for 4 weeks in a row).
Sponsors
University Medical Centre Groningen
Department of Hematology
Prof. J.C. Kluin-Nelemans
Hanzeplein 1
9713 GZ Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients: - Patients with regular heavy menstrual bleeding (=menorrhagia). - Age over 18 years. - Written informed consent. Inclusion criteria for healthy controls with regular menstrual blood loss: - Age over 18 years. - Written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients: - Patients with postmenopausal, postcoital or intermenstrual bleeding - Patients with an intra-uterine device or hormonal treatment. - Patients with anticoagulant, antithrombotic therapy or use of non-steroidal anti-inflammatory drugs (NSAID’s). - Patients with uterine fibroids > 2 cm in diameter. - Patients with a Body Mass Index >30 kg/m2. - Patients with a Pictorial Bleeding Assessment Chart-score 30 kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Investigate the cyclic variation in clot lysis time in women with HMB in comparison to controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Investigate the cyclic variation in TAFI, PAI-1, tPA, PI, thrombin generation, fibrin clot permeation and confocal microscopy analysis of fibrin clots in women with HMB in comparison to controls. - Investigate the ovulatory menstrual cycle by measuring progestagen. | — |
Contacts
Public ContactS. Wiewel-Verschueren
Hanzeplein 1
Outcome results
None listed