Hyperbaric oxygen and pulmonary toxicity

Molecular detection of pulmonary oxygen toxicity using exhaled breath analysis after hyperbaric hyperoxic exposure.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON22684

Enrollment

Registered

2017-06-30

Start date

2018-01-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ENG: pulmonary oxygen toxicity, oxygen diving, oxygen poisoning. DUTCH: pulmonale zuurstof toxiciteit, zuurstof duiken, zuurstofvergiftiging.

Interventions

a) Submersed exposure (diving) wit a PO2 of 190 kPa or PO2 40 kPa for 60 minutes. b) Series of dry exposures (recompression chamber) with a PO2 250 kPa for 90 minutes in 5 days plus once after 2 days

Eligibility

Inclusion criteria

Inclusion criteria: - Adult males or females - Non-smoking - Fit to dive according to the European Diving Technology Committee (EDTC) standards. (includes lung function tests such as DLCO % reference ERS/ATS > 70%) - Certified Navy (Special Forces) Divers (only applicable to wet-dives) - Certified hyperbaric Navy personnel (only applicable to dry-dives)

Exclusion criteria

Exclusion criteria: - If one of the inclusion criteria is not met - Recent lower respiratory tract infection and/or flue - Daily use of alcoholic beverages - Use of (over the counter) medication

Design outcomes

Primary

Measure	Time frame
Changes in EB, DLNO/CO compared to baseline after air and oxygen dives.	—

Secondary

Measure	Time frame
a. Difference in EB measured by SpinoNose or GCMS. b. Time interval post-dive which gives the best markers for POT.	—

Contacts

Public ContactT.T. Wingelaar

Royal Netherlands Navy, Diving Medical Center

tt.wingelaar@mindef.nl+31 223 653 076

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)