The effect of endurance exercise training on muscle mass gains during subsequent resistance exercise training in older adults

The impact of aerobic exercise pre-conditioning to maximize the skeletal muscle adaptive response to resistance type exercise training in healthy older adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON22675

Enrollment

Registered

2018-12-20

Start date

2019-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcopenia

Interventions

- Endurance exercise (if allocated to intervention group) - Resistance exercise (all participants)

Eligibility

Inclusion criteria

Inclusion criteria: • Age between 65 and 85 y • BMI between 18.5 and 30 kg/m2

Exclusion criteria

Exclusion criteria: • HbA1C level above 6.5% • Fasted blood glucose level above 6.9 mmol/L and/or 2 hour OGTT glucose level higher than 11.1 mmol/L • Smoking • Diabetes • Cancer • Cardiovascular disease • Arthritic conditions • A history of neuromuscular problems • Cognitive Impairment • COPD • Renal disorder • Participation in any structured exercise program • Hypertension, high blood pressure that is above 140/90 mmHg • Pulmonary disease • Known allergic reaction to ultrasound contrast-agent

Design outcomes

Primary

Measure	Time frame
•Type II muscle fiber size (muscle biopsy)	—

Secondary

Measure	Time frame
• Muscle fiber vascularization (muscle biopsy) • Muscle microvascular perfusion (CEUS) • Whole-body skeletal muscle mass (MRI) • Whole-body and regional body lean tissue mass (DEXA) • Muscular strength (1 RM – each exercise machine) • Aerobic capacity (VO2peak cycling test) • Physical performance (short physical performance battery, timed up-and-go, handgrip strength) • Metabolic health (OGTT) • Acute muscle satellite cell response to a single bout of exercise (muscle biopsy)	—

Measure

Time frame

• Muscle fiber vascularization (muscle biopsy) • Muscle microvascular perfusion (CEUS) • Whole-body skeletal muscle mass (MRI) • Whole-body and regional body lean tissue mass (DEXA) • Muscular strength (1 RM – each exercise machine) • Aerobic capacity (VO2peak cycling test) • Physical performance (short physical performance battery, timed up-and-go, handgrip strength) • Metabolic health (OGTT) • Acute muscle satellite cell response to a single bout of exercise (muscle biopsy)

—

Contacts

Public ContactMilan Betz

Maastricht University

m.betz@maastrichtuniversity.nl0433881509

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)