Rectal cancer
Conditions
Interventions
Digital FDG-PET/CT, DW-MRI.
Sponsors
Leiden Unversity Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Biopsy proven adenocarcinoma of the rectum Patients with locally advanced rectal cancer who, according to current guidelines, are eligible for treatment with neoadjuvant chemoradiation Patients treated in the LUMC, HMC, Alrijne Leiderdorp or Groene Hart Ziekenhuis Gouda. Age 18 years and older; Willing to participate in all aspects of the study
Exclusion criteria
Exclusion criteria: Patients with rectal cancer, receiving chemoradiation as part of the TESAR trial Diabetes mellitus Claustrofobia (low dose benzodiazepines are allowed) Prior radiotherapy to the pelvis If female and fertile: signs and symptoms of pregnancy or a positive pregnancy test / breast-feeding (a formal negative pregnancy test is not obligatory Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule Contraindications for Magnetic Resonance Imaging Patient has evidence of infection in the 14 days prior to the FDG-PET/CT scan localised to the lower abdomen, pelvic region, lower back, inguinal region Inability to tolerate lying supine for the duration of an FDG-PET/CT examination (~30min)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SUVmax, ADC | — |
Secondary
| Measure | Time frame |
|---|---|
| TLG, SUVmax change | — |
Contacts
Public ContactFloris Vuijk
Leiden University Medical Center
Outcome results
None listed