Cystic fibrosis, CF.
Conditions
Interventions
No interventions, this is an observational study.
Sponsors
H.A.W.M. Tiddens, M.D., PhD.
and
ms. E.M. Bakker, M.D.
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for children with CF: 1. Age 0 – 4 years (0 up to and including 4 years); 2. Diagnosis of CF confirmed by sweat-test and/or DNA analysis and/or electro physiology testing (nasal potential difference measurement or intestinal current measurement); 3. Clinically stable patients: no hospital admission and no need for an antibiotic course for at least 4 weeks prior to enrolment in the study; 4. No signs of acute viral respiratory infection in the period from 1 week (7 days) before the measurement until the day of the measurement. An acute viral respiratory infection is defined as a combination of the following symptoms: rhinitis; pharyngitis; cough; headache; fever; 5. Signed written informed consent. Inclusion criteria for healthy children: 1. Age 0-4 years; 2. No use of an antibiotic course (for pulmonary reasons) for at least 4 weeks prior to enrolment in the study; 3. No signs of respiratory infection in the period from 1 week (7 days) before the measurement until the day of the measurement; 4. Signed written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for children with CF: 1. Medical conditions that might affect the measurements (e.g. cardiac problems that can influence saturation); 2. Pulmonary exacerbation at the time of the study. Exclusion criteria for healthy children: 1. Medical conditions that might affect the measurements (e.g. cardiac problems that can influence saturation); 2. History of pulmonary diseases such as asthma, BPD, airway malacia; 3. Current use of pulmonary drugs; 4. History of premature birth; 5. ENT related interventions in recent history (< 1 month), such as tonsillectomy, antibiotics for ENT infections, grommets, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurements of overnight SpO2, gas mixing and overnight cough. | — |
Contacts
Public ContactE.M. Bakker
Erasmus Medical Center, Sophia Children’s Hospital, Department of Pediatric Pulmonology (room Sb-2666) Dr. Molenwaterplein 60
Outcome results
None listed