Epithelial Ion Transport Defects in Pancreatitis: establishment of an organoid model

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON22666

Enrollment

Registered

2021-10-06

Start date

2021-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatitis

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: All patients undergoing pancreatoscopy within the framework of regular diagnostics or treatment.

Exclusion criteria

Exclusion criteria: A potential subject that is younger than 18 years old will be excluded from participation in this study.

Design outcomes

Primary

Measure	Time frame
The ability to culture PDEC organoids from pancreatic duct biopsies.	—

Secondary

Measure	Time frame
- PDEC organoid characteristics (cellular and molecular composition) - Ability to grow PDEC monolayers - Ion transport (chloride and bicarbonate) in PDEC monolayers - Ion transport (chloride and bicarbonate) in duodenal monolayers - Carrier status for pancreatitis-related mutations	—

Contacts

Public ContactDora Angyal

Erasmus Medical Center Rotterdam

d.angyal@erasmusmc.nl+31641126920

Outcome results