alcohol addiction / alcohol verslaving repetitive Transcranial Magnetic Stimulation (rTMS) / repetitieve Transcraniële Magnetische Stimulatie treatment / behandeling functional Magnetic Resonance Imaging (fMRI)
Conditions
Interventions
One group will receive rTMS treatment, and the other group will receive sham rTMS treatment.
Sponsors
AMC, department of psychiatry, Addiction care
Eligibility
Inclusion criteria
Inclusion criteria: - Men and women. - Age between 25-65. - Recent DSM-V diagnosis (mild, moderate and severe) of alcohol use disorder (2 weeks after detox) and will be in treatment during the entire stimulation period (2 weeks after inclusion). - Sufficient speaking and understanding of Dutch language.
Exclusion criteria
Exclusion criteria: - A DSM-V diagnosis of schizophrenia or another psychotic disorder, personality disorder or sleep disorder. - TMS contraindications: history of epileptic seizures or epilepsy in a first degree relative, irregular sleep/ wake rhythm. - MR contraindications (only relevant for the 40 participants who will undergo MR scanning): metal implants, claustrophobia. - No drug use during the treatment process other than drugs prescribed by their practitioner in order to overcome their alcohol dependence. - IQ under 80 - Endocrinological disorders or regular use of corticosteroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total number of abstinent days at six months follow up: See Schluter, R. S., van Holst, R. J., & Goudriaan, A. E. (2018). Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependence: study protocol of a randomized controlled clinical trial of efficacy and working mechanisms. BMC psychiatry, 18(1), 1-12. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are changes in craving (immediately after 2-week rTMS treatment; at 3-months and at 6-months and 12-months past treatment; changes in SST, AAT (cognitive tasks), and changes in (f)MRI measures immediately after rTMS treatment | — |
Contacts
Public ContactRenée Schluter
Academisch Medisch Centrum - Afdeling psychiatrie, PA3.225
Outcome results
None listed