The immune system and microbial tone in relation to NAFLD/NASH before and after BARIatric surgery in the morbidly obese in Amsterdam; the BARIA cohort study.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON22589

Enrollment

1500

Registered

2016-07-13

Start date

2016-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesity nafld-nash bariatric surgery

Interventions

bariatric surgery

Eligibility

Inclusion criteria

Inclusion criteria: - Scheduled for bariatric surgery - Ability to provide informed consent - No more than 5% weight loss in 6 months prior to surgery - No more than 3% weight loss in 1 month prior to surgery

Exclusion criteria

Exclusion criteria: - Known genetic basis for insulin resistance or glucose intolerance - All medical and psychiatric conditions except for obesity related diseases.

Design outcomes

Primary

Measure	Time frame
To identify microbial, immunological and metabolic markers associated with weightloss after bariatric surgery. To this end, we will collect before, during surgery and after 2 years follow up.	—

Secondary

Measure	Time frame
To apply systems biology approach to identify hierarchy of driving mechanisms (microbial, immunological and metabolic markers) in relation to diet and satiety involved in the long term beneficial weight loss effects of bariatric surgery that can be used for personalised medicine	—

Contacts

Public ContactM. Nieuwdorp

AFDELING INWENDIGE GENEESKUNDE AMC MEIBERGDREEF 9, KAMER F4.159.2

m.nieuwdorp@amc.uva.nl+31 (0)20 5666612

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)