Subarachnoid haemorrhage from a ruptured cerebral aneurysm, aSAH, delayed cerebral ischaemia, DCI.
Conditions
Interventions
For copeptin levels in the aSAH group, blood will be drawn in an extra serum tube of 5 ml on the first 24 hours of admission at the ICU.
Sponsors
Intensive Care
St. Elisabeth Hospital Tilburg
Hilvarenbeekseweg 60
5022 GC Tilburg
+31(0)135393808
Eligibility
Inclusion criteria
Inclusion criteria: Admission to the intensive care of the St. Elisabeth Hospital Tilburg. Age 18 year or over. Start clinical symptoms of SAH within 24hr at admission. Informed consent to participate in the trial. Aneurysm confirmed by computerized tomography angiography (CT-A) with or without digital substraction angiography (DSA). Blood drawn after obtaining informed consent on the first 24 hours of admission at de ICU.
Exclusion criteria
Exclusion criteria: Less than 18 years of age. Severe language barrier, unable to read the informed consent. SAH due to non- aneurysmal causes. Recent ischemic or hemorrhagic stroke (< 30 days). Recent intracerebral hemorrhage without subarachnoid blood (< 30 days). Existing recent head trauma (< 30 days). Recent acute myocardial infarction (AMI)(< 30 days). Chronic heart failure. Recent acute exacerbation of COPD (AECOPD) (< 30 days). Recent sepsis/septic shock (< 30 days). Recent acute pancreatiits (< 30 days). Liver cirrhosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to investigate the ability of copeptin to predict poor one-year functional outcome, GOS 1-3, in patients with aneurysmal SAH in the Dutch population. | — |
Secondary
| Measure | Time frame |
|---|---|
| •Development of DCI •Case fatality 30 days after admission •One year mortality •Functional outcome 12 months after aSAH, assessed by both the Glasgow Outcome Scale and the modified Ranking Scale. | — |
Contacts
Public ContactJ.A.H. Oers, van
internist-intensivist Intensive Care St. Elisabeth Hospital Tilburg Hilvarenbeekseweg 60
Outcome results
None listed