EN: Alzheimer's Disease, Inactivity, ApoE-e4, genetic vulnerability for Alzheimer's Disease NL: ziekte van Alzheimer, dementie, inactiviteit, ApoE-e4 dragerschap, genetische kwetsbaarheid voor Alzheimer
Conditions
Interventions
INTERVENTION
The intervention studied is the COACH method, a 12 week pedometer based exercise counseling strategy, aimed at enhancing low-to-moderate daily physical activity. The method is based on t
Miller & Rollnick, 1991
Rubak, Sandbaek, Lauritzen, & Christensen, 2005). Six individual coaching sessions will be scheduled to guide the individual in assessing and obtaining personal activity goals. Five sessions are sched
Calfas et al., 1996). All coaching sessions in the trajectory of the participants will be performed by the same coach.
CONTROL
Participants in the control group receive 5 individually guided muscle
Sponsors
Clinical Neuropscyhology section, Vrije Universiteit Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, participants must meet all of the following criteria: age ≥ 55 years; able to perform the Timed Up & Go Test with or without assistive device, and a Mini Mental State Examination (Folstein, Folstein, & McHugh, 1975) score higher than 25. Both males and females will be included. In the second part of the study only those participants who display low levels of physical activity as measured in Part 1 of the study are recruited.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: wheelchair bound, cardiovascular problems that limit physical activity, epilepsy, presence of neurodegenerative disorder or focal neurological deficit, diagnosis of dementia or mild cognitive impairment, progressive or terminal disease, depression, history of alcoholism, severe visual problems, severe auditory problems and problems with the Dutch language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main outcome measure is cognitive function, measured with neuropsychological tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are physical functioning measured with performance-based field tests, IGF-1 and BDNF serum levels and ADLs, mood and quality of life, measured by questionnaires | — |
Contacts
Public ContactSara Galle
van der Boechorststraat 1 room 1F-62
Outcome results
None listed