COPD exacerbation nebulization inhalation amoxicillin
Conditions
Interventions
Nebulization of amoxicilline clavulanic acid. They will receive treatment by inhalation of 25/5 mg nebulised amoxicillin clavulanic acid twice daily instead of oral or intravenously administered amoxi
Sponsors
Dr. P.D.L.P.M. van der Valk
Eligibility
Inclusion criteria
Inclusion criteria: 1. A clinical diagnosis of COPD, as defined by GOLD criteria; 2. Admitted with signs and symptoms of an exacerbation of COPD, defined as an acute negative change from the baseline, reported by the patient, in dyspnoea and/or sputum volume and/or colour of sputum (yellowish or greenish sputum) and/or cough; 3. Age 40 years or over; 4. Current or former smoker.
Exclusion criteria
Exclusion criteria: 1. Current treatment with amoxicillin or amoxicillin clavulanic acid; 2. Impaired renal function (GFR < 30); 3. Current pneumonia, defined as an acute respiratory tract illness associated with radiographic shadowing on a chest radiograph which was neither pre-existing nor of any other cause; 4. Allergy for penicillin, amoxicillin or clavulanic acid; 5. Respiratory insuffiency and hypercapnia measured by arterial blood gas analyses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sputum concentration of amoxicillin at day 3. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of hospitalization. | — |
Contacts
Public ContactP.D.L.P.M. Valk, van der
Medisch Spectrum Twente Hospital Department of Pulmonology PO Box 50.000
Outcome results
None listed