Cystic Fibrosis Oral glucose tolerance test Diabetes
Conditions
Interventions
All subjects included into this study will be administered in the hospital after three days of high carbohydrate intake and an overnight fasting of at least 8 hours. Subjects will be questioned about
Sponsors
Initiator
Eligibility
Inclusion criteria
Inclusion criteria: 1. Cystic Fibrosis patients 2. Proven diagnosis cystic fibrosis: either positive genotyping or raised sweat sodium 3. > 18 years 4. Stable disease 5. Regularly attending outpatients clinic
Exclusion criteria
Exclusion criteria: 1. Absent oral glucose tolerance test in last half year 2. Cystic fibrosis-related diabetes diagnosis 3. Organ tranplantation in history 4. Pregnancy 5. Current use of medications interfering with glucose tolerance 6. Current or recent pulmonary exacerbation requiring oral or intravenous antibiotics in the past 4 weeks 7. Medical conditions other than cystic fibrosis interfering with glucose tolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose levels, blood insulin levels and blood C-peptide levels during OGTT and after OGTT during a follow-up period of 3 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin resistance and ß-cell function, calculated respectively by HOMA-IR and HOMA-B. Areas under the curve for glucose, insulin and c-peptide levels. Peak glucose levels. | — |
Contacts
Public ContactJ.M.W. Berg, van den
Haga teaching Hospital Leyweg 275
Outcome results
None listed