Adult onset asthma Severe asthma Phenotyping Markers
Conditions
Interventions
None listed
Sponsors
Amsterdam Medical Centre, department of pulmonology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 18-75 years; 2. Physicians diagnosis of asthma after age of 18; 3. Physicians diagnosis of asthma >1 year prior enrolment; 4. Documented reversibility in FEV1>12% and 200 ml or Airway hyperresponsiveness to inhaled methacholine (PC2020% (with twice daily reading >10%).
Exclusion criteria
Exclusion criteria: 1. Smoking history >10py and a fixed airflow obstruction (FEV1 12% and 200ml; 2. Pregnancy; 3. Physician's diagnosis of asthma in childhood; 4. Other pulmonary diseases or non related major co-morbidities; 5. Diffusion capacity (TLCO/VA) <80%; 6. Episodes of dyspneu or multiple use of inhalde pulmonary medication in childhood (5-12yr).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Studie 1: Characterizing patients with adult onset asthma with respect to clinical, functional and inflammatory parameters. Subtypes will be defined by cluster analysis; risk factors of disease and poor quality of life will be defined. Studie 2: Clinical, functional and inflammatory parameters will be compared between 100 patients with recent onset asthma (1-5yr) and 100 patients with longstading adult onset asthma (>5yr). Studie 3: Three well defined subtypes will be compared by measurements of small airway function and sputum cells. | — |
Contacts
Public ContactM. Amelink
Outcome results
None listed