Hyperlipidaemia Hypertriglyceridaemia
Conditions
Interventions
Cold exposure via a water-perfused cooling suit.
High fat milkshakes
Sponsors
Maastricht university
Eligibility
Inclusion criteria
Inclusion criteria: - Signed informed consent - Caucasian - Aged 20-50 years at the start of the study - Body mass index (BMI) 20-30 kg/m2 - Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3 months - Stable sedentary lifestyle (not more than 2 hours of sports per week) - Female participants: Using Microgynon 30 or levonorgestrel/ethinylestradiol
Exclusion criteria
Exclusion criteria: - Use of cholesterol or lipid-lowering medication - Active pregnancy during the study period - Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other) - Participation in earlier research that included PET/CT scanning for detection of brown adipose tissue activity in the last 3 months - Alcohol consumption of >2 servings per day - Smoking in the past 6 months - Haemoglobin content <8.4 mmol/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial triglyceride metabolism: post prandial TG levels Postprandial lipoprotein metabolism: post prandial values of other lipoproteins besides TG Presence and activity (glucose uptake) of brown adipose tissue measured by a 18F-FDG PET/CT scan Muscle mitochondrial respiration Metabolic parameters of sympathic activity: plasma catecholamines | — |
Secondary
| Measure | Time frame |
|---|---|
| Core body temperature Skin body temperatures | — |
Contacts
Public ContactMichiel Moonen
G2.206
Outcome results
None listed