epidural, bupivacaïne, sufentanil, morphine, analgesia, side effects Epiduraal, morfine, analgesie, bijwerkingen
Conditions
Interventions
Patients are randomly assigned in two treatment groups:
1. Bupivacaïne 2.5 mg/ml + morphine 0.08 mg/ml (group BM)
2. Bupivacaïne 2.5 mg/ml + sufentanil 1 ug/ml (group BS).
Before surgery a epidural catheter is inserted. After surgery patients are receiving either continuous epidural bupivacaïne with morphine (BM
Sponsors
UMCU
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older; 2. Scheduled major surgery; 3. Indication for epidural catheter according to the responsible anaesthesiologist.
Exclusion criteria
Exclusion criteria: 1. Patients with an allergy to one of the study medications; 2. Patients using opioids pre-operatively; 3. Patients who are not speaking Dutch; 4. Patients with mental disability; 5. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The pain scores during the first 72 hours after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| The quality of pain relief (as experienced by the patient) and side/adverse effects: pruritis, drowsiness, nausea, vomiting and/or motor block, sedation, respiratory depression and episodes of hypotension. | — |
Contacts
Public ContactA.M. Karsch
Divisie Peri-operatieve Zorg en Spoedeisende Hulp (DP&S), Universitair Medisch Centrum Utrecht
Outcome results
None listed