Esophageal cancer
Conditions
Interventions
Paravertebral catheter analgesia combined with patient-controlled intravenous opioids.
Sponsors
University Medical Center Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: Patients who are older than 18 years old, able to provide written informed consent, and scheduled to undergo minimally invasive esophagectomy with an intrathoracic anastomosis and two-field lymphadenectomy (Ivor Lewis procedure) will be included.
Exclusion criteria
Exclusion criteria: - ASA >III / severe comorbidity - Coagulation disorders that prohibit epidural analgesia according to the Nederlandse Vereniging voor Anesthesiologie (NVA) guideline “Neuraxisblokkade en antistolling†- Other contraindications for epidural analgesia - Allergy to local anesthetics - Chronic opioid use prior to esophagectomy (>3 months) - Renal failure, i.e. eGFR < 50 - Unable to complete questionnaires in the language of the country in which the trial is conducted - Cervical lymph node dissection (i.e. 3-field lymphadenectomy) - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery as measured by the Quality of Recovery 40 (QoR-40) questionnaire on the morning of postoperative day 3. | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-40 questionnaire score Area Under the Curve on day 1-3, the integrated pain and systemic opioid score and patient satisfaction and pain experience according to the International Pain Outcomes (IPO) questionnaire, cost-effectivenes, additional rescue medication on day 0-3, opioid consumption on day 0-3, technical failure of the pain treatment, duration of anesthesia time, duration of surgery, total postoperative fluid administration day 0-3, postoperative vasopressor and inotrope use, length of urinary catheter use, length of hospital stay, postoperative complications, chronic pain at six months after surgery, and other adverse effects. | — |
Contacts
Public ContactFeike Kingma
University Medical Center Utrecht
Outcome results
None listed