Preeclampsia
Conditions
Interventions
Omeprazole 40mg once daily
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: Women (=18 years) with a singleton pregnancy diagnosed with PE with a gestational age of = 20 weeks and <35 weeks admitted to the obstetric department who give written informed consent, will be included.
Exclusion criteria
Exclusion criteria: - Multiple pregnancies - Not willing to give written informed consent. - Other reasons than (suspected) PE requiring hospitalization - The use of PPI at time of randomization - Contraindications or hypersensitivity to PPI use - The use of medication affected by PPI - Fetal death at time of inclusion - Signs of fetal distress at time of inclusion - Expected delivery of = 2 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in sFlt-1 levels in women who have received PPI, in comparison to women who have not received PPI. | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference in other biomarkers such as PlGF, ET-1, sEndoglin, CT-proET-1 in women who have received PPI, in comparison to women who have not received PPI | — |
Contacts
Public ContactRugina Neuman
Erasmus Medical Center
Outcome results
None listed