Vaststellen van ziekteverwekkers van griepachtige verschijnselen bij ouderen.

Identification of pathogens responsible for influenza-like illness in elderly in The Netherlands.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON22474

Enrollment

2500

Registered

2012-04-06

Start date

2011-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infectious diseases, influenza, viral and bacterial co-infections, carriage (in Dutch: infectieziekten, griep, virale en bacteriele infecties, dragerschap)

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. ≥ 60 years of age; 2. Willing to present when influenza-like-illness (ILI) symptoms occur; 3. Signed Informed Consent.

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

Measure	Time frame
Presence of influenza A and B virus in nasal swab during ILI episodes.	—

Secondary

Measure	Time frame
1. Subtyping of influenza viruses in case of influenza infection; 2. Antibody levels to influenza virus; 3. Presence of viral (other than influenza A or B) and bacterial microorganisms in nasal and transoral nasopharyngeal swabs respectively after reporting of ILI by the participants during ILI episodes and 8 weeks later. The following micro-organisms will at least be screened by PCR or conventional bacterial culture: human parainfluenza virus, RSV A and B, adenovirus, coronavirus, hMPV, human rhinovirus, bocavirus and polyomaviruses, Mycoplasma pneumoniae, S. pneumoniae, H. influenzae, M. catarrhalis, S. aureus, N. meningitidis and B. pertussis. Other pathogens might be added if diagnosis is still inconclusive or if other pathogens become prevalent during this season. Additional pneumococcal serotyping may be performed by multiserotype PCR; 4. Presence of S. pneumoniae in saliva; 5. Antibody levels towards viral and bacterial pathogens present in the swabs as identified by PCR or bacterial culture; 6. A SF-36 (short-form health survey) questionnaire at baseline.	—

Measure

Time frame

1. Subtyping of influenza viruses in case of influenza infection; 2. Antibody levels to influenza virus; 3. Presence of viral (other than influenza A or B) and bacterial microorganisms in nasal and transoral nasopharyngeal swabs respectively after reporting of ILI by the participants during ILI episodes and 8 weeks later. The following micro-organisms will at least be screened by PCR or conventional bacterial culture: human parainfluenza virus, RSV A and B, adenovirus, coronavirus, hMPV, human rhinovirus, bocavirus and polyomaviruses, Mycoplasma pneumoniae, S. pneumoniae, H. influenzae, M. catarrhalis, S. aureus, N. meningitidis and B. pertussis. Other pathogens might be added if diagnosis is still inconclusive or if other pathogens become prevalent during this season. Additional pneumococcal serotyping may be performed by multiserotype PCR; 4. Presence of S. pneumoniae in saliva; 5. Antibody levels towards viral and bacterial pathogens present in the swabs as identified by PCR or bacterial culture; 6. A SF-36 (short-form health survey) questionnaire at baseline.

—

Contacts

Public ContactR.A.J. Boxtel, van

Antonie van Leeuwenhoeklaan 9-11

renee.van.boxtel@rivm.nl+31 (0)30 2742755

Outcome results